Journal article
Type I natural killer T cells suppress tumors caused by p53 loss in mice
JB Swann, AP Uldrich, S Van Dommelen, J Sharkey, WK Murray, DI Godfrey, MJ Smyth
Blood | AMER SOC HEMATOLOGY | Published : 2009
Abstract
CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53+/- mice lacking either type I NKT cells (TCR Jα18-/-) or all CD1d-restricted T cells (CD1d-/-). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by..
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Awarded by National Cancer Institute
Funding Acknowledgements
[ "We thank Shannon Griffiths and Michelle Stirling for maintaining the mice at the Peter MacCallum Cancer Centre.", "This work was supported by a National Health and Medical Research Council of Australia Program grant ( 454569; M.J.S., D.I.G.), Doherty Fellowship (A.P.U.) and Research Fellowships (M.J.S., D.I.G.), National Institutes of Health grant R01CA106377, and an Australian Postgraduate Award (J.B.S.)." ]